D-Glucosamine hydrochloride, Chondroitin sulfate (sodium salt), Methylsulfonylmethane (MSM), Hydroxypropyl methylcellulose capsule (plant based capsule shell), Hyaluronic acid (sodium), Collagen, Ascorbic acid (vitamin C), Zinc bisglycinate, Thiamine HCL (vitamin B1), Pyridoxal-5'-Phosphate -Monohydrate (Vitamin B6), Manganese gluconate-Dihydrate, Copper sulfate-Anhydrate, Methylcobalamin (Vitamin B12), Sodium selenite

Recommended Dosage:

Take 2 x 2 capsules daily with plenty of liquid, ideally half an hour before a meal.

Cautions:

The specified, recommended consumption quantity must not be exceeded. Food supplements are not intended as a substitute for a balanced and varied diet and a healthy lifestyle. Not suitable for children, adolescents, pregnant and breastfeeding women. Keep out of reach of small children. 

Not suitable for people taking anticoagulant medication, pregnant or breastfeeding women.

Storage:

Store in a cool, dry place, away from light and out of the reach of small children.

Intake in combination with medication or with pre-existing conditions:

Consult your doctor or pharmacist before consumption.

Allergens and additives:

Vegan. Free from lactose, gluten, coloring agents. According to the law without preservatives.

Information at a glance:

Arthrokombi capsules contain a unique blend of glucosamine, chondroitin sulfate, collagen, hyaluronic acid, vitamin C, trace elements (manganese, zinc, selenium, copper) and certain B vitamins. This unique combination supplies optimal nutrients to the joints.

• Glucosamine is an endogenous sugar-produced naturally in the body. It is a component of connective tissue, cartilage and synovial fluid. Cartilage covers and protects the ends of the bones and allows the bones to move smoothly against each other
• Chondroitin is the main component of articular cartilage and provides stability and elasticity
• Hyaluronic acid (HA) is a substance that retains moisture. This substance occurs naturally in many parts of the human body, including the skin, eyes, and the synovial fluid of the joints
• Collagen is one of the body's most important building proteins. It is the most important component of connective tissue and thus a component of cartilage, bones, teeth, tendons, ligaments, skin and muscles.

For this reason, it makes sense to use collagen and hyaluronic acid for joints during heavy physical exertion and pain.

• MSM : MSM (methylsulfonylmethane = organic sulfur compound) is an important component of connective tissue and cartilage. 
• The body needs vital substances such as the trace elements copper and manganese to maintain the joints. Manganese is required as an important co-enzyme for both collagen and connective tissue synthesis:

- Copper and manganese contribute to the maintenance of normal connective tissue

- Zinc and manganese contribute to the maintenance of normal bones

- Selenium, zinc and manganese protect the cells against oxidative stress

• Vitamin C contributes to normal collagen formation for normal function

- blood vessels

- bones

- cartilage function

• Vitamin B1, B6, B12 contribute to a normal energy metabolism

Due to legal regulations, it is prohibited to make specific statements about the effectiveness of certain ingredients in our products. This is the reason why there is very little to no information on the effects of some products.

Approved statements of effect:

Vitamin B1 (Thiamine):

• contributes to normal mental function
• contributes to normal energy metabolism
• contributes to the normal functioning of the nervous system
• contributes to normal heart function

Vitamin B6 (Pyridoxine):

• contributes to normal cysteine ​​synthesis
• contributes to normal energy metabolism
• contributes to normal homocysteine ​​metabolism
• contributes to normal mental function
• helps reduce fatigue
• contributes to the normal functioning of the nervous system
• contributes to protein and glycogen metabolism
• contributes to the normal formation of red blood cells
• contributes to the normal function of the immune system
• contributes to the regulation of hormonal activity

Vitamin B12 (Methylcobalamin):

• contributes to normal energy metabolism
• contributes to the normal functioning of the nervous system
• contributes to normal homocysteine ​​metabolism
• contributes to normal mental function
• contributes to the normal formation of red blood cells
• contributes to the normal function of the immune system
• contributes to the reduction of tiredness and fatigue
• has a role in cell division

Vitamin C

• contributes to normal collagen formation for the normal function of blood vessels and bones
• contributes to normal collagen formation for normal cartilage function and
• contributes to normal collagen formation for normal function of the gums
• contributes to normal collagen formation for normal function of the skin and teeth
• contributes to the normal functioning of the nervous system and energy metabolism
• contributes to normal mental function and the immune system
• helps protect cells from oxidative stress
• contributes to the reduction of tiredness and fatigue
• contributes to the regeneration of the reduced form of vitamin E

Zinc

• contributes to a normal acid-base metabolism
• contributes to normal cognitive function
• contributes to normal fertility and normal reproduction
• contributes to normal fatty acid metabolism
• contributes to normal vitamin A metabolism
• contributes to the maintenance of normal bones and vision
• contributes to the maintenance of a normal function of the immune system
• has a function in cell division
• contributes to normal carbohydrate metabolism
• contributes to normal DNA synthesis
• contributes to the maintenance of normal testosterone levels
• contributes to normal protein synthesis
• contributes to the maintenance of normal hair, nails and skin

Manganese

• contributes to normal energy metabolism
• contributes to the maintenance of normal bones
• contributes to the normal formation of connective tissue
• Selenium contributes to the protection of cells from oxidative stress
• contributes to normal spermatogenesis
• contributes to the maintenance of normal hair, nails
• contributes to the normal functioning of the immune system
• contributes to normal thyroid function
• contributes to the protection of cells from oxidative stress

Copper

• contributes to the maintenance of normal connective tissue
• contributes to normal energy metabolism
• contributes to the normal functioning of the nervous system
• contributes to normal hair pigmentation
• contributes to normal iron transport in the body
• contributes to normal skin pigmentation
• contributes to the normal functioning of the immune system
• contributes to the protection of cells from oxidative stress

Studies

1. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis https://pubmed.ncbi.nlm.nih.gov/17516722/
2. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial https://pubmed.ncbi.nlm.nih.gov/16309928/
3. [Hyaluronic acid in the treatment of osteoarthritis of various localization: A review] https://pubmed.ncbi.nlm.nih.gov/36286983/
4. Vitamin C May Help to Reduce the Knee's Arthritic Symptoms. Outcomes Assessment of Nutriceutical Therapy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643354/
5. Zinc supplements and bone health: The role of the RANKL-RANK axis as a therapeutic target https://pubmed.ncbi.nlm.nih.gov/31653549/